关于Textbook of Bone Metastases的原因,关于Textbook of Bone Metastases的相关知识。 Bone metastasis is an important clinical problem affecting approximately 350,000 people in the United States. After tumors have metastasized to bone, the cancer becomes incurable. In clinical trials in the past, bone metastases were not considered independently, but they have become an important focus of research now that new therapies that are effective in decreasing the incidence of skeletal complications are available. Textbook of Bone Metastases is a comprehensive bench-to-bedside reference book that also provides a very good review of the basic science underpinning the metastatic process.
The section on clinical features and assessment is important in a book for specialists in internal medicine and oncology. Many chapters contain redundant material, which reflects the book's contributions from multiple authors but also frees the reader of a chapter from being required to read other chapters for the necessary background information.
There is a heavy emphasis on osteolytic metastasis throughout the book, and the discussion of osteoblastic metastases is somewhat out of date. In the chapters on imaging methods, only techniques that are available in Europe and the United Kingdom are reviewed, and techniques such as positron-emission tomography with computed tomography, which are available in the United States, are not mentioned. The chapter on immunotherapy has questionable relevance to the treatment of bone metastasis; it contains no discussion of this subject, except in the conclusions.
The chapters on the use of bisphosphonates to treat bone metastasis and the mechanisms of action of these drugs are very good and probably should precede the chapter on osteoclast inhibitors. The chapter on cost implications of bisphosphonate therapy is an important one, since it is still unclear with which bisphosphonates, when, or for how long patients should be treated. The chapter on the psychosocial aspects of metastasis and bone metastasis discusses a subject that is frequently overlooked in most review books and is well done.
The final section of the book is a mini-textbook on oncology, focused on breast cancer, prostate cancer, multiple myeloma, and malignant non-Hodgkin's lymphoma, as well as on other tumors that metastasize to bone. This information could probably have been included in previous chapters that discuss these cancers and bone metastasis. This section is good, however, for medical students or orthopedists who want more information on these types of cancers in a unified section. Overall, this textbook is comprehensive and will be a useful reference for medical students, oncologists, orthopedists, and general practitioners alike.
G. David Roodman, M.D., Ph.D.
University of Pittsburgh School of Medicine
Pittsburgh, PA 15213
roodmangd@upmc.edu (文章出处：《新英格兰医药杂志》)
The section on clinical features and assessment is important in a book for specialists in internal medicine and oncology. Many chapters contain redundant material, which reflects the book's contributions from multiple authors but also frees the reader of a chapter from being required to read other chapters for the necessary background information.
There is a heavy emphasis on osteolytic metastasis throughout the book, and the discussion of osteoblastic metastases is somewhat out of date. In the chapters on imaging methods, only techniques that are available in Europe and the United Kingdom are reviewed, and techniques such as positron-emission tomography with computed tomography, which are available in the United States, are not mentioned. The chapter on immunotherapy has questionable relevance to the treatment of bone metastasis; it contains no discussion of this subject, except in the conclusions.
The chapters on the use of bisphosphonates to treat bone metastasis and the mechanisms of action of these drugs are very good and probably should precede the chapter on osteoclast inhibitors. The chapter on cost implications of bisphosphonate therapy is an important one, since it is still unclear with which bisphosphonates, when, or for how long patients should be treated. The chapter on the psychosocial aspects of metastasis and bone metastasis discusses a subject that is frequently overlooked in most review books and is well done.
The final section of the book is a mini-textbook on oncology, focused on breast cancer, prostate cancer, multiple myeloma, and malignant non-Hodgkin's lymphoma, as well as on other tumors that metastasize to bone. This information could probably have been included in previous chapters that discuss these cancers and bone metastasis. This section is good, however, for medical students or orthopedists who want more information on these types of cancers in a unified section. Overall, this textbook is comprehensive and will be a useful reference for medical students, oncologists, orthopedists, and general practitioners alike.
G. David Roodman, M.D., Ph.D.
University of Pittsburgh School of Medicine
Pittsburgh, PA 15213
roodmangd@upmc.edu (文章出处：《新英格兰医药杂志》)
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